Round 2 : 33 player drafted
Detroit Alex Mack C
  California 6-4 311
Round 2 : 34 player drafted
New England James Laurinaitis IB
  Ohio State 6-3 240
Round 2 : 35 player drafted
St. Louis Brian Robiskie WR
  Ohio State 6-3 205
Round 2 : 36 player drafted
Cleveland Sean Smith CB
  Utah 6-4 214
Round 2 : 37 player drafted
Seattle Clint Sintim LB
  Virginia 6-3 254
Round 2 : 38 player drafted
Cincinnati Brian Cushing LB
  USC 6-3 245
Round 2 : 39 player drafted
Jacksonville Donald Brown TB
  Connecticut 5-10 210
Round 2 : 40 player drafted
Oakland D.J. Moore CB
  Vanderbilt 5-9 185
Round 2 : 41 player drafted
Green Bay Shonn Greene TB
  Iowa 5-11 235
Round 2 : 42 player drafted
Buffalo Clay Matthews LB
  USC 6-4 240
Round 2 : 43 player drafted
San Francisco Louis Delma FS
  Western Michigan 5-11 197
Round 2 : 44 player drafted
Miami Ziggy Hood DT
  Missouri 6-3 295
Round 2 : 45 player drafted
NY Giants Shawn Nelson TE
  Southern Mississippi 6-5 240
Round 2 : 46 player drafted
Houston Tyson Jackson DE
  LSU 6-5 292
Round 2 : 47 player drafted
New England Connor Barwin LB
  Cincinnati 6-4 252
Round 2 : 48 player drafted
Denver Aaron Maybin LB
  Penn State 6-4 249
Round 2 : 49 player drafted
Chicago Kenny Britt WR
  Rutgers 6-3 215
Round 2 : 50 player drafted
Cleveland Max Unger C
  Oregon 6-5 300
Round 2 : 51 player drafted
Dallas Sen'Derrick Marks DT
  Auburn 6-1 305
Round 2 : 52 player drafted
NY Jets Michael Johnson DE
  Georgia Tech 6-7 260
Round 2 : 53 player drafted
Philadelphia Eric Wood C
  Louisville 6-4 304
Round 2 : 54 player drafted
Minnesota Jamon Meredith T
  South Carolina 6-5 300
Round 2 : 55 player drafted
Atlanta Cornelius Ingram TE
  Florida 6-4 235
Round 2 : 56 player drafted
Miami Victor Harris CB
  Virginia Tech 6-0 186
Round 2 : 57 player drafted
Baltimore Marcus Freeman LB
  Ohio State 6-1 240
Round 2 : 58 player drafted
New England Rashad Johnson FS
  Alabama 6-0 187
Round 2 : 59 player drafted
Carolina Juaquin Iglesias WR
  Oklahoma 6-0 204
Round 2 : 60 player drafted
NY Giants Jonathan Luigs C
  Arkansas 6-4 314
Round 2 : 61 player drafted
Indianapolis Louis Murphy WR
  Florida 6-2 204
Round 2 : 62 player drafted
Tennessee Duke Robinson G
  Oklahoma 6-5 330
Round 2 : 63 player drafted
Arizona James Casey TE
  Rice 6-4 240
Round 2 : 64 player drafted
Pittsburgh Mike Mickens CB
  Cincinnati 6-0 176