| Round 1 : 1 player drafted | ||
| Detroit | Matthew Stafford | QB |
| Georgia | 6-2 225 | |
| Round 1 : 2 player drafted | ||
| St. Louis | Aaron Curry | LB |
| Wake Forest | 6-2 247 | |
| Round 1 : 3 player drafted | ||
| Kansas City | Eugene Monroe | T |
| Virginia | 6-5 310 | |
| Round 1 : 4 player drafted | ||
| Seattle | Jason Smith | T |
| Baylor | 6-5 310 | |
| Round 1 : 5 player drafted | ||
| Cleveland | Andre Smith | T |
| Alabama | 6-4 332 | |
| Round 1 : 6 player drafted | ||
| Cincinnati | Brian Orakpo | DE |
| Texas | 6-3 263 | |
| Round 1 : 7 player drafted | ||
| Oakland | Michael Crabtree | WR |
| Texas Tech | 6-2 215 | |
| Round 1 : 8 player drafted | ||
| Jacksonville | Jeremy Maclin | WR |
| Missouri | 6-0 200 | |
| Round 1 : 9 player drafted | ||
| Green Bay | B.J. Raji | DT |
| Boston College | 6-1 323 | |
| Round 1 : 10 player drafted | ||
| San Francisco | Everette Brown | LB |
| Florida State | 6-2 256 | |
| Round 1 : 11 player drafted | ||
| Buffalo | Brandon Pettigrew | TE |
| Oklahoma State | 6-6 260 | |
| Round 1 : 12 player drafted | ||
| Denver | Mark Sanchez | QB |
| USC | 6-2 225 | |
| Round 1 : 13 player drafted | ||
| Washington | Michael Oher | T |
| Mississippi | 6-5 310 | |
| Round 1 : 14 player drafted | ||
| New Orleans | Vontae Davis | CB |
| Illinois | 6-0 203 | |
| Round 1 : 15 player drafted | ||
| Houston | Malcolm Jenkins | CB |
| Ohio State | 6-1 201 | |
| Round 1 : 16 player drafted | ||
| San Diego | Eben Britton | T |
| Arizona | 6-6 310 | |
| Round 1 : 17 player drafted | ||
| NY Jets | Josh Freeman | QB |
| Kansas State | 6-6 248 | |
| Round 1 : 18 player drafted | ||
| Denver | Peria Jerry | DT |
| Mississippi | 6-2 290 | |
| Round 1 : 19 player drafted | ||
| Tampa Bay | Larry English | LB |
| No. Illinois | 6-2 254 | |
| Round 1 : 20 player drafted | ||
| Detroit | William Beatty | T |
| Connecticut | 6-6 307 | |
| Round 1 : 21 player drafted | ||
| Philadelphia | Knowshon Moreno | TB |
| Georgia | 5-10 217 | |
| Round 1 : 22 player drafted | ||
| Minnesota | Percy Harvin | WR |
| Florida | 5-11 195 | |
| Round 1 : 23 player drafted | ||
| New England | Alphonso Smith | CB |
| Wake Forest | 5-9 191 | |
| Round 1 : 24 player drafted | ||
| Atlanta | Rey Maualuga | IB |
| USC | 6-3 255 | |
| Round 1 : 25 player drafted | ||
| Miami | Darrius Heyward-Bey | WR |
| Maryland | 6-2 206 | |
| Round 1 : 26 player drafted | ||
| Baltimore | Robert Ayers | DE |
| Tennessee | 6-3 273 | |
| Round 1 : 27 player drafted | ||
| Indianapolis | LeSean McCoy | TB |
| Pittsburgh | 5-11 210 | |
| Round 1 : 28 player drafted | ||
| Philadelphia | Jared Cook | TE |
| South Carolina | 6-5 245 | |
| Round 1 : 29 player drafted | ||
| NY Giants | Hakeem Nicks | WR |
| North Carolina | 6-1 215 | |
| Round 1 : 30 player drafted | ||
| Tennessee | Darius Butler | CB |
| Connecticut | 5-11 178 | |
| Round 1 : 31 player drafted | ||
| Arizona | Chris "Beanie" Wells | TB |
| Ohio State | 6-1 235 | |
| Round 1 : 32 player drafted | ||
| Pittsburgh | Jarron Gilbert | DT |
| San Jose State | 6-6 288 | |